Anyway - I somehow managed to get her to come to UC Davis to give a talk last year just as the book was going viral. In preparation for Skloot's visit I decided to do some sort of "open access" schtick and looked into how many papers about HeLa cells were in Pubmed Central. Pubmed Central is a database of papers for which the full text is available at no charge. After this mini-research and after interacting with Rebecca over the last year and seeing the well deserved recognition of her book, I have been a bit fascinated about how much of the literature surrounding studies of HeLa cells is openly and/or freely available.
Studies on the propagation in vitro of poliomyelitis viruses. IV. viral multiplication in a stable strain of human malignant epithelial cells (strain hela) derived from an epidermoid carcinoma of the cervix. William F. Scherer, Jerome T. Syverton, and George O. Gey. J Exp Med. 1953 May 1; 97(5): 695–710.
I believe this was the first full paper published discussing HeLa cells. Nice short title by the way. Anyway - good to see it in Pubmed Central.
TISSUE CULTURE STUDIES OF THE PRO-
LIFERATIVE CAPACITY OF CERVICAL
CARCINOMA AND NORMAL EPITHE-
LIUM. George O. Gey,Ward D. Coffman*
and Mary T. Kubicek *(Departments of
Surgery and Gynecology, Johns Hopkins
Hospital and University, Baltimore 5, Md.
This is a report of an evaluation in vitro of the
growth potential of normal, early intra-epithelial,
and invasive carcinoma from a series of cases of
cervical carcinoma. Comparable cytological and
tissue culture studies were actually carried out on
selected biopsies of normal and neoplastic areas of
the same cervix. Thus far, only one strain of epi-
dermoid carcinoma has been established and
grown in continuous roller tube cultures for al-
most a year. It grows well in a composite medium
of chicken plasma, bovine embryo extract, and
human placenta! cord serum. The autologous nor-
mal prototype is most difficult to maintain under
comparable cultural conditions. Most of the tissue
from other cases showed rapid keratinization of
the cells grown in cultures whether from normal
or neoplastic areas. Some of the hormonal aspects
of the problem will be discussed.
- Active Immunization Against Poliomyelitis
- Use of Human Cancer Cells to Diagnose Poliomyelitis
- Poliomyelitis Viruses in Tissue Culture
- THE BINDING OF PENICILLIN IN RELATION TO ITS CYTOTOXIC ACTION : III. THE BINDING OF PENICILLIN BY MAMMALIAN CELLS IN TISSUE CULTURE (HELA AND L STRAINS)
- GROWTH CHARACTERISTICS OF POLIOMYELITIS VIRUS IN HELA CELL CULTURES: LACK OF PARALLELISM IN CELLULAR INJURY AND VIRUS INCREASE
- The Viral Range in Vitro of a Malignant Human Epithelial Cell (Strain HeLa, Gey): I. Multiplication of Herpes Simplex, Pseudorabies, and Vaccinia Viruses
John Hogenesch from U. Penn made a nice figure of relevance and agreed to let me post it:
And he comments "You can see several things, Nixon's "war on cancer" in the early 70s and the dawn of the cell/molecular biology age in the 80s and expansion in the 90s."
Thanks John ...