Sunday, June 05, 2022

Monday, May 16, 2022

Videos about using the UCSC Genome Browser for analysis of SarsCOV2

 These look pretty useful and thought I would post here. Text is from the UCSC Youtube channel

This 5-part video series is for virologists and public health researchers interested in leveraging the UCSC Genome Browser and web interface to UShER (Ultrafast Sample placement on Existing tRees). These tools are a 'one-stop shop' to understand SARS-CoV-2 through genome annotations as well as track variants by placing your samples in a phylogenetic tree with millions of other SARS-CoV-2 sequences. Use the SARS-CoV-2 Genome Browser: http://bit.ly/sarscov2browser Visit our SARS-CoV-2 Genome Browser and UShER quick start page with videos, scripts and more: http://bit.ly/ucsccovidbrowser COVID-19 Research at UCSC: https://genome.ucsc.edu/covid19.html 'The UCSC SARS-CoV-2 Genome Browser' publication: https://www.nature.com/articles/s4158... 'Ultrafast Sample placement on Existing tRees (UShER) enables real-time phylogenetics for the SARS-CoV-2 pandemic' publication: https://www.nature.com/articles/s4158... UShER documentation, installation, source code:: https://github.com/yatisht/usher https://usher-wiki.readthedocs.io/en/... COVID-19 Genomic Epidemiology Toolkit module "Realtime Phylogenetics with UShER: https://www.cdc.gov/amd/training/covi... Learn more about the UCSC Genome Browser: http://genome.ucsc.edu https://twitter.com/genomebrowser Learn more about the UCSC Genomics Institute: https://twitter.com/ucscgenomics https://genomics.ucsc.edu/

Saturday, April 23, 2022

Endosymbiosis Animations for "Biodiversity and the Tree of Life"

So I am in the midst of co-teachign a very large introductory biology course at UC Davis "BIS2C - Biodiversiy and the tree of Life". I cover much of microbial diversity in this class and also the large scale structure of the Tree of Life. 

As always, I spent a lot of time working on slides and such for this class and recently posted some animations based on these slides to Twitter and Facebook and thought I would share some of them here. For today, I am sharing the animations I made on Endosymbiosis. I posted a first version of this to Twitter last week. Note - I added music - Mussorgsky - Night on Bald Mountain for drama ... I also posted it to Facebook:

  

And boy am I glad I did. Because multiple people commented and pointed out parts that were, well, not correct. I had lecture too soon to fix them so I told my students about this and that I would update the slides. I then spent a day updating everything and made a new version which I think is much much better.

 

Tuesday, April 05, 2022

A good bye to my beloved Clover

 

Monday, March 28, 2022

The ongoing saga with the UC Health Insurance Pharmacy "Benefits" Via Navitus

Well the saga continues. Here is an update.


It all started March 7. See here for a long thread and also responses. See this thread in an easier to read format here: https://threadreaderapp.com/thread/1500934973775249412.html See this thread in an easier to read format here https://threadreaderapp.com/thread/1506297722776657920.html And then I got told Navitus was going to be instructed to cover my insulins by UCOP but the message clearly was not recieved. And finally and thankfully today I was told my insulins would be covered. I am now interested in what is happening to others out there who have been harmed by the UC / Navitus system.

Wednesday, March 23, 2022

Some links to articles about Diabetes and COVID19

Posted some links to Twitter that I am compiling here too about type 1 diabetes and COVID19 with a focus on recommendations for diabetics in current COVID situation



See also


Independent risk factors of COVID-19 pneumonia in vaccinated Mexican adults

Risk Factors for Severe COVID-19 Outcomes Among Persons Aged ≥18 Years Who Completed a Primary COVID-19 Vaccination Series — 465 Health Care Facilities, United States, December 2020–October 2021

Age, Underlying Conditions Top Factors in Breakthroughs

 A Wall Street Journal analysis found that among fully vaccinated people, the ones most likely to be hospitalized with breakthrough infections of COVID-19 are the elderly and those with specific underlying medical conditions.

“In particular, people with diabetes, chronic lung disease, kidney disease and compromised immune systems were at risk of serious outcomes from breakthrough cases,” The Journal reported.











 

Lots of useful responses to question "What should high risk people do in face of relaxed masking requirements"?

 

So I posted this to Twitter.
And got lots of useful resposnes. Rather than compile them here if interested people should browse the responses.

Tuesday, March 22, 2022

The ongoing disaster of the new UC Health Insurance Pharmacy "benefits"

Recently I posted to Twitter about the disastrous new University of California Pharmacy Benefits system.
In summary, I got a letter in March that warned me of something that was about to happen in January (that is, in the past).  And what was about to happen was bad - cutting off coverage of my insulin.  And the system in place for trying to even find out what was going on and what to do about this was a disaster.

I note, this generated an enormous response and it was clear that this was not just me experiencing the disaster of their system.

I used the threadfreader app to make this into a more easily readable thread here: https://threadreaderapp.com/thread/1500934973775249412.html

A few people pointed me to some contacts at UC Davis to reach out to and I did.  They were both great and very helpful.  They told me that the UC was working on dealing with many of these issues and some of those responses were rolled out quickly. 

And I posted about how these efforts were sort of helpful but not ideal. For example




On March 21, I got a detailed email from the University of California apologizing for the situation and detailing many changes to apparently try and help fix things.  I mean, they never should have done this and used this incredibly cheap, low grade system.  But at least they are trying to fix things.

Below is the email from UC. More about this in a bit but I wanted to share the full text for people to see here.

An important message from UC about your pharmacy benefits

Dear Jonathan,

We are writing to acknowledge — and apologize for — the problems many members of the UC community are experiencing with Navitus Health, a new administrator of pharmacy benefits for UC employee and Medicare PPO plans, and to let you know what we are doing to fix the problems.

Last year, University of California Health (UCH) and UC Systemwide Human Resources selected Navitus Health to administer pharmacy benefits, starting Jan. 1, 2022. This decision was made following an extensive formal bid process, conducted by a committee with representatives from UCH, Systemwide HR, UC faculty with pharmacy expertise and UC’s retiree association. 

Navitus was selected as the partner that could provide UC with the best overall flexibility, service, and affordability. However, since UC’s transition to Navitus Health, we have heard from too many members who have been negatively impacted by this change. 

Some members have had to change prescription drugs, been required to complete time-consuming authorization processes and experienced denials by Navitus, causing unnecessary anxiety and frustration. Navitus failed to meet the scheduled target date for mailing a clinical transition letter, causing hardship and worry for faculty, staff, retirees and their family members.  

Additionally, like many employers Navitus has faced customer service staffing challenges, leading to wait times that far exceed Navitus’ standards and UC performance guarantees. Among other things, this has put undue pressure on benefits professionals at UC locations and in the UC Retirement Service Center and the UCPath Center, as they have worked to provide support that should be handled by Navitus.

We take these problems — and our responsibility to ensure that members of UC health plans have access to the prescriptions they need — very seriously. UCH and UC Systemwide Human Resources have been in constant communication with Navitus, and we want to let you know what we are doing to fix these problems.

Support with member transitions
  • Due to the delay in mailing clinical transition letters, Navitus has provided an extended transition period to the end of April for drugs that are not covered. Extension letters and an email campaign were recently initiated.
  • Navitus will call members who need to transition to new medications directly and offer help with authorizations, denials, and appeals. Those who have experienced a denial for a Not Covered/Non-Formulary medication will also receive a phone call offering help. 
  • UCH, Alliant (a UC consultant) and Navitus will audit and review the protocols Navitus uses for denials to ensure they are in alignment with Navitus internal guidelines, industry standards and Medicare guidelines – and to identify and correct any gaps. 

Customer service improvements
  • Navitus has committed to adding an additional 35 customer service representatives (an increase from 125 to 160) by the end of April, and hopes to add another 15 staff after that, along with additional support for UC benefits professionals.
  • Navitus has also added two more personnel with pharmacy clinical expertise to help UC benefit professionals support members.
  • In addition, Navitus is exploring a concierge-type customer service model to ensure UC members receive the dedicated assistance they need.

Again, we sincerely apologize for any difficulties you or your family members have experienced during this transition. We are committed to you receiving the critical health care you deserve, without unnecessary inconvenience or frustration.

Sincerely,
 
Cheryl Lloyd                                                    Dr. Carrie Byington
Vice President                                                 Executive Vice President
Systemwide Human Resources                      University of California Health


Please do not reply to this message. Replies to this message are routed to an unmonitored mailbox. 

Saturday, March 19, 2022

Baby Hummingbirds at Yolo Bypass

 

So I got a glimpse of a hummingbird nest at Yolo Bypass And then I went back and got a better look at it , with babies ... And I posted some videos too





Friday, February 11, 2022

A field guide to SarsCOV2

 

Gave a talk on SarsCOV2 to the Yolo County Community of Practice group. I basically discussed how the concept of a field guide can be useful for thinking about SarsCOV2. Here are my slides I will try to post the recording of the talk at some point.

Monday, January 10, 2022

Best Pics from Nimbus Fish Hatchery

Went to Sacramento for a Doctor's appointment and then had a 2 hour Zoom call. Decided to do the call while walking around the Nimbus Fish Hatchery which I have never been to. I heard that people had seen a rare duck there so went on over. And it was awesome. I then messaged a grad student in my lab, Alonna Wright who lives nearby and she came over for a walk after lunch. Here is a link to a slideshow of some of the pics I got

Friday, January 07, 2022

Some thoughts on Omicron and COVID19 in the last week or so

 

Some recent Tweets and threads from me on Omicron and related topics

Tuesday, December 28, 2021

Tribute to EO Wilson

 

Sunday, December 12, 2021

Video and slides of my talk for the Microbiome Virtual International Forum posted

I gave a talk last week for the Microbiome Virtual International Forum. https://www.microbiome-vif.org/ Title: Evolution of microbiomes and the evolution of the study and politics of microbiomes (or, how can something be both ridiculously overhyped and horrifically underappreciated)" 

 See the Youtube video:  

 Slides:


Also see this Twitter thread for some more info:

Wednesday, November 17, 2021

Saturday, November 06, 2021

Videos of Talks from the JGI "NeLLi (New Lineages of Life)" Meeting Now Available

Recently the DOE JGI Hosted the "NeLLi" meeting on New Lineages of life.  See agenda here: https://usermeeting.jgi.doe.gov/2021-nelli/2021-nelli-agenda/ 


There were a whole series of interesting talks in this program and now the videos are available on Youtube. 

See Youtube Channel or the embedded video link below.


Sunday, May 16, 2021

Some thoughts on the CDC new mask guidance

 

See this thread 

Made into a thread reader thread here: https://threadreaderapp.com/thread/1393025234303741954.html 

Saturday, March 27, 2021

Compiling some of my Twitter comments about the evolution and origins of SarsCoV2/ COVID19

 News Stories Quoted in


Twitter Threads








Tuesday, October 20, 2020

New article out from the Eisen Lab: Isolation and sequence-based characterization of a koala symbiont: Lonepinella koalarum

See Isolation and sequence-based characterization of a koala symbiont: Lonepinella koalarum 

Paper based on PhD thesis work of Katie Dahlhausen and wrap up of analysis led by Laetitia Wilkins. 

Full citation:

Dahlhausen KE, Jospin G, Coil DA, Eisen JA, Wilkins LGE. 2020. Isolation and sequence-based characterization of a koala symbiont: Lonepinella koalarum. PeerJ8:e10177 https://doi.org/10.7717/peerj.10177

Acknowledgements. We thank Céline Caseys ORCID: 0000-0003-4187-9018 for her idea to search eggNOG annotations against KEGG Class 1.11 Xenobiotics biodegradation and metabolism pathways; Chris Brown ORCID: 0000-0002-7758-6447 for his script to download assemblies in batch from GenBank; Cassandra L. Ettinger ORCID: 0000-0001-7334-403X for valuable comments on the pangenome analysis and help with revising the figures. We also thank Dr. Joseph Gillespie ORCID: 0000-0002-5447-7264, Dr. Raphael Eisenhofer ORCID: 0000-0002-3843-0749 and two anonymous reviewers for comments on the submitted manuscript. Isolate 16S Sanger sequencing was performed at the UC Davis College of Biological Sciences DNA Sequencing Facility.

Monday, August 24, 2020

Great horned owl at #YoloBypass

 

Went for a walk at Yolo Bypass 8/23/2020 early in the AM and got a nice view of a Great Horned Owl. Here are some pics.

Saturday, June 20, 2020

Introducing "Hammerhead Man" - the superhero you did not know you needed.

So I was digging through some old school papers because my daughter asked me what books they had use write reports on in high school and, well, I have a lot of my English papers from high school in a box in a closet.  

And in digging through this box I found a short story I wrote for a creative writing class from freshman year in college, which was taught by Catherine Tudish. 

Now, mind you, I was not in a good place when I wrote this as I was reading from the death by suicide of my father.  And, possibly related to that I truly have almost no memory of writing this, other than the concept of the assignment. But I read it to my kids. And, well, I actually like it.  It has a lot of issues.  But I think it should be expanded on. I may just revisit this.

So - here is the official first release of "Hammerhead Man".  With corrections and comments from Catherine Tudish. 
















Saturday, June 06, 2020

Brief summary of the gear I use for photography (of mostly birds)

So - many people have asked what gear I use for my photography (mostly of birds). Here is a quick summary. See some of my pictures here: https://jonathaneisen.smugmug.com



Camera: Nikon D500




 Lenses Birding: Nikkor 200-500 f/5.6
 

 Macro: Nikkor 105 mm f/2.8
 


Based on review of Mark Smith.

See more detail in this blog post here. "Stalking the wild garganey in West Sacramento #birding #eBird #iNaturalist #birdphotography #nikonD500.




Wednesday, April 22, 2020

Slides I have used for "Biodiversity and the Tree of Life" at @ucdavis

I have posted the slides I have used so far in remote teaching for "Biodiversity and the Tree of Life" - aka Bis2C - at UC Davis and I thought I would share them here.

Many of the figures are from "Life v 11" by Hillis et al. which is the textbook we have been using for the class. I have been told in the past by the publishers that this was OK to do so I am assuming it is still OK. Hope there are not too many errors ... for some reason Lecture 10 will not upload - working on it





















Saturday, April 04, 2020

Today's stay at home activity - virtual tour of the Dali museum

Love that the Dean of the College of Biological Sciences Mark Winey sent out a suggestion to check out this virtual tour of the Dali Museum in his regular message to the college.  And it is pretty cool. Check it out: Visit the museum as you have never done before! | Fundaci� Gala - Salvador Dal�

Another #NatureAtHome project: Never Home Alone:

This is another nice at home activity relating to Nature.  Rob Dunn and colleagues have been running this  Wildlife of Your Homes project in various ways for many years.  And it is easy to participate in it via iNaturalist. Take pics of bugs or other critters in your home and then post them and add them to the iNaturalist project.  See Never Home Alone: The Wild Life of Homes � iNaturalist.

Another #NatureAtHome project: Never Home Alone:

This is another nice at home activity relating to Nature.  Rob Dunn and colleagues have been running this  Wildlife of Your Homes project in various ways for many years.  And it is easy to participate in it via iNaturalist. Take pics of bugs or other critters in your home and then post them and add them to the iNaturalist project.  See Never Home Alone: The Wild Life of Homes � iNaturalist.

Resource for #NatureAtHome: California Academy of Sciences

OK have not been posting much to this blog for a few weeks due to the disruption from the coronavirus but I am going to start posting again when I find things that may be of use for the new world of social distancing, etc.



Today I am posting about the California Academy of Sciences which has a nice page compilation information and resources they have for activities at home: Academy @ Home | California Academy of Sciences



Thanks Cal Academy.


Tuesday, March 17, 2020

Collecting some of my comments about Sacramento County's poor response to COVID19

Posted this rant on March 9

And then another rant
And this one
And then Placer and Yolo County came out with their somewhat more aggressive plan
And more
And this
And another And this And another And another

Tuesday, March 10, 2020

My posts about #UCDavis and #Covid19

Going to use this page to keep track of some of what I have been posting about what is going on at UC Davis in regard to the coronavirus.  Will add more later ... but just going to use this to keep track.

February 26

Things blew up at @ucdavis with reports that the 1st community acquired case of COVID19 was at our hospital. I received an email about this that I eventually posted to Twitter (I waited to post until I saw others reporting this)
Tons of stories came out over the next few weeks about this and I will add some links to them. But eventually, attention went elsewhere as the 1st large clusters of cases that were detected in the US ended up being in other locations.

March 7.

Actions from UC Davis announced regarding COVID19 was, well, better than nothing but pretty limited.


March 10. 

UC Davis expanded actions.


Most recent post

A ton to be thankful for -- here is one part of that - all the acknowledgement sections from my scholarly papers

So - it is another Thanksgiving Day and in addition to thinking about family, and football, and Alice's Restaurant, I also think a lot a...