For those interested in microbiomes it is definitely worth looking at this paper: BMC Genomics | Abstract | Whole genome and exome sequencing of monozygotic twins discordant for Crohn's disease
Simple summary - they have sets of identical twins where one twin has Crohn's and the other does not. They looked for somatic mutations that could like the ones with Crohn's and did not find any. Sure - a negative result. Could be anything. But the next obvious thing to do (which they report they are already doing) is to look at the microbioata in these people. Alas, they probably do not have data from before these people got Crohn's, but still, this could be interesting ...
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I wonder if its worth looking at different tissues in cases like these? Could there also be changes in specific tissues? If there is somatic mosaicism between twins there may be somatic mosasicism within one person.....
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