Tuesday, December 11, 2012

Award: Ridiculous, absurd, offensive overselling of the microbiome from Chalmers & Gothenburg

Wow.  This is painful.  There is a press release that came out a few days ago: Changes in the gut bacteria protect against stroke.  In it they report on a new paper showing some interesting results comparing the metagenomes of gut microbiota in stroke patients vs healthy patients.  They found some interesting differences.  And they then made absurd, dangerous, self-serving claims that completely confuse the issue of correlation vs. causation.

Basically, they found carotenoid production genes to be more abundant in the people who were healthy.  And they then appear to have concluded that production of carotenoids by bacteria in the gut protects from strokes.  Completely ridiculous.  No evidence whatsoever is presented that such production of carotenoids by gut microbes does anything of the kind.   Compare the semi careful wording in the paper
Our finding of enriched levels of phytoene dehydrogenase in the metagenomes of healthy controls and its association with elevated levels of β-carotene in the serum may indicate that the possible production of this anti-oxidant by the gut microbiota may have a positive health benefit
To the drivel in the release
Our results indicate that long-term exposure to carotenoids, through production by the bacteria in the digestive system, has important health benefits. These results should make it possible to develop new probiotics. We think that the bacterial species in the probiotics would establish themselves as a permanent culture in the gut and have a long-term effect

As a bonus, they promote a new company of their Metabogen in the press release.   Here's a suggestion.  Do not invest in this company and do not believe anything they do (unless they retract the claims in the PR).  The people involved in this press release, which also are associated with this company, are overselling their own work, do not seem to understand the difference between correlation and causation, and are making dangerous claims about health benefits.

And thus I am awarding them my coveted "Overselling the microbiome award."  Past awards include:
UPDATE 1: 7:30 PM 12/11/12

Some of the other parts of the press release that are bad:
  • The title: "Changes in the gut bacteria protect against stroke." Are you kidding me?  Ridiculous claim with no evidence.
  • Another line: "Jens Nielsen, Professor of Systems Biology at Chalmers, says that it may be preferable to take probiotics instead – for example dietary supplements containing types of bacteria that produce carotenoids."  So now they have jumped from a correlation in what microbes are present to treating people with probiotics.  Just what priobiotics are they going to use? And is there any evidence that they help?

1 comment:

  1. I just caught this as I "drove by", and don't know the background, but I HATE when scientists (using the term loosely) take results to mean causation where absolutely none exists. It always happens where there's financial gain at stake, and you can bet it's in a multi level marketing scheme. Aargh! Thanks for fighting the good fight.Carry on.


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