Thursday, October 30, 2014

Rediscovering some critical terms of use in microbial discussions: #microbiomania and #microbophobia

Earlier this week I was trying to come up with a short term to use when referring to the "Overselling of the Microbiome" and related hype. And I came up with one I really really like: microbiomania. The term just captures the essence of hype about microbiomes to me I guess.

So - of course - the first thing to do was to see if anyone else used this term.  And the number one thing I looked at was domain names.  Nope.  Microbiomania.Com and Microbiomania.Org are now mine.  And then I started to search the interwebs. And surprsingly there was not much (in English at least).  But some links showed up to books in Google Books with passages from > 100 years ago.  And this is when the digging got to be fun.  Here are some of the things I found.

1. A section from "The Medical Era"


When copying this section of the search results I discovered Google Books has an embed tool for Google Books though not sure how well it works: here is a try




Anyway - the text of this section of the book reads:

The Paris correspondent of the Chicago Tribune in a recent letter says We hear very little now of microbist or anti microbist theories Dr Koch's so called discovery is regarded with skepticism though not refuted The truth is his assertions are generally held to be not proven Dr Peters the favorite pupil of the great surgeon Dr Trousseau denounces what he calls microbiomania as a social danger and declares that the micro bians doctrine is vain sterile and objectionable in every way as both needlessly alarming and wrongly reassuring 
So I guess there were some folks who did not like the Koch and his silly theories about germs.

2. The Eclectic Medical Journal Volume 48


OCR text:
Microbiomania For five or six years past says Semolla you could not open a journal without encountierng an alleged discovery of one or more pathogenic bacilla and it is not necessary for me to tell you that the surest means of attaining celebrity is to discover in such and such a malady a new bacillus or a minute micrococcus I can not tell you what ridiculous puerilities have been brought forth by the imagination of physicians who are incapable of serious work and according to the rules of experimental medicine mount every new idea as though it were a triumphal car and think that in celebrating and exaggeraring its praises they manifest their love of progress 

Pretty awesome stuff I think.


3. The Louisville Medical Journal also comes up with a hit to microbiomania


Here is the attempt at an embed:



and the OCR interpreted text reads
and microbophobists The feeling against the theory of the microbial origin of cholera is very strong and was expressed by Prof Peter both at the Academy and the School of Medicine in these terms It is a pure satisfaction of natural history to say with the German School that there exists a microbe producer I say that there is a microbe product The parasitic doctrines have engendered a microbiomania which determined a terror which will be the opprobrium of the 19th century
Faris December 12 1884 
Now - nevermind that the OCR is not perfect (where is Faris?).  But not only is this fascinating.  But the beginning of the page has another word that seems worthy of resurrecting: microbophobists,  And this pulls up all sorts of fascinating discussions:



And the related search is perhaps more fascinating: microbophobia



So - in the end I did not come up with a totally new word.  But I do now have two words I really want to use more often and which I will use in the following ways:

  • Microbiomania which I define here as the overselling of the impact (beneficial or detrimental or otherwise) of microbiomes without the evidence to support such impact 
  • Microbophobia which I define here as the overwhelming and unreasonable fear of microbes (of any kinds).  This is similar in concept to "germophobia" but gets around the issue some people have with whether "germ" is a term that should be reserved for pathogens and thus that germophobia could be viewed as the fear of pathogens.  

Wednesday, October 29, 2014

CEO of Soylent goes even further off the deep end - going after his microbiome

Well, this is pretty deranged: Soylent CEO Is Lifehacking Water By Pissing In the Sink.  Forget all the wackiness of Soylent and the idea of limiting water intake.  And just look at the part of this on the micro biome
Feces are almost entirely deceased gut bacteria and water. I massacred my gut bacteria the day before by consuming a DIY Soylent version with no fiber and taking 500mg of Rifaximin, an antibiotic with poor bioavailability, meaning it stays in your gut and kills bacteria. Soylent's microbiome consultant advised that this is a terrible idea so I do not recommend it. However, it worked. Throughout the challenge I did not defecate.
So - he took Rifaximin to kill his gut microbiome because he thought that would help him not defecate.  And then because he did not defecate he concluded that the Rifaximin played some role in such anti-defecation?  OMFG.  This is both bad science and some, well, crazy a*s-sh*t.  I - I - I - I just do not know what else to say.

Hat tip to Andrea Kuszewski.

Monday, October 27, 2014

Some suggestions for having diverse speakers at meetings

Been having a lot of discussions online in response to my post (Apparently, the National Academy of Sciences thinks only one sex is qualified to talk about alternatives to sex #YAMMM) tracking the awful gender ratio for speakers and session chairs at meetings run by the National Academy of Sciences in their Sackler series.  Some people were asking what one can do to improve gender diversity at meetings so I thought I would post this which I was meaning to do anyway ...

-------------------------------------------------------

I wrote this in an email to a meeting organizer after I had turned down their invitation due to the imbalance in gender of the speakers (more about this another time --- this is not the same case as the one I wrote about here: Turning down an endowed lectureship because their gender ratio is too skewed towards males #WomenInSTEM). 

Anyway, my colleague wrote a long and very helpful email to me after I withdrew from the meeting when I saw the speaker list.  In the email she detailed things that her organization was trying to do to increase diversity of speakers at meetings.  She ended it with this:
Thus, I take your comment to heart and wanted you to know that I care about this issues as well.  I would love to hear how you balance these inequities at your meetings and learn as much as I can.  Thank you for taking the time to bring this up I know how busy you are and appreciate your candor. Truly looking forward to more scientific exchanges and perhaps some education around gender issues.
And I wrote back, quickly, without digging into the literature or all the posts in the world about this some quick suggestions which I think others might find useful. So here is my response - again - was not meant to cover all the things one can do - just examples:

Thanks so much for the response and I am really glad to see all you are trying to do in this area. 
In terms of how we try to balance inequities at meetings I organize I would note a few simple things
  1. Do not try to invite only the famous people or the people doing the "top" work.  This usually biases one towards more established researchers (as in, older) and this alas also usually is accompanied by distortion of diversity.
  2. DO try to invite people across the breadth of career stages.  Meetings to me should not be only about getting the PIs whose labs are doing the best work to talk.  It should also be about giving opportunities to junior researchers - PhD students, post docs and junior faculty who are doing exciting work - perhaps more focused or smaller scale - but nevertheless exciting.  If one opens up a invited speaker list to people at diverse career stages one generally greatly increases the gender and ethnic diversity. 
  3. DO try to invite people from diverse institutions - research universities, research institutes, companies, non profits, NGOs, the press, non research universities, and more.
  4. DO try to be flexible about times and dates for talks - I have found that women more than men have other commitments (e.g. kids) for which they cannot change dates of activities. 
  5. DO try to provide child care assistance (as you are doing).
  6. DO try to make sure women are on the organizing committee See http://www.theatlantic.com/technology/archive/2014/01/the-easiest-possible-way-to-increase-female-speakers-at-conferences/282858/
  7. DO make sure to provide travel funds.
  8. DO try to include some talks on related areas that may not be the main theme of the conference.  For example history of science and ELSI related topics increase the pool of women and speakers with diverse backgrounds which can be invited.
  9. DO ask the women who turn down invitations if they care to say why.
  10. DO commit to spending a decent amount of time searching for qualified female speakers.  Sometimes there are people who fit ALL the goals of a meeting and they are just missed because women on average have lower public profiles than men doing the same type of work.
Just some ideas off the top of my head.
Jonathan
see also 
http://www.stemwomen.net/jonathan-eisen/ 
and 
http://phylogenomics.blogspot.com/p/posts-on-women-in-science.html

Friday, October 24, 2014

Apparently, the National Academy of Sciences thinks only one sex is qualified to talk about alternatives to sex #YAMMM

Just got this email from Francisco Ayala:
January 9-10, 2015 
In the Light of Evolution IX. Clonal Reproduction: Alternatives to Sex 
Organizers: Michel Tibayrenc, John C. Avise and Francisco J. Ayala 
Beckman Center of the National Academies, Irvine, CA 
Evolutionary studies of clonal organisms have advanced considerably in recent years, but are still fledgling. Although recent textbooks on evolution and genetics might give the impression that nonsexual reproduction is an anomaly in the living world, clonality is the rule rather than the exception in many viruses, bacteria, and parasites that undergo preponderant asexual evolution in nature. Clonality is thus of crucial importance in basic biology as well as in studies dealing with transmissible diseases. 
This Colloquium will bring together specialists in various disciplines, including genetics, evolution, statistics, bioinformatics, and medicine. A balance will be sought between the various disciplines, including clonal animals and plants, animal and human cloning, pathogens, and cancer studies.   
Registration is now open http://www.nasonline.org/programs/sackler-colloquia/upcoming-colloquia/ILE_IX_Clonal_Reproduction.html
Registration fee is $150. 
Graduate students and postdoctoral researchers are eligible for discount fee of $100. 
All meals, break and reception refreshments listed on the agenda are included in the registration fee.
For more information, contact sackler@nas.edu.
Could be interesting right?  Alas, then, I clicked on the link.  And I discovered the meeting could also be referred to as "Only one sex talks about alternatives to sex".  Men are highlighted in yellow. Women highlighted in green. (Note - I am making some guesses as to gender but I think these are reasoably accurate).

Thursday, October 23, 2014

Microbiology Book for Kids: It's Catching by Jennifer Gardy and Josh Holinaty

A few days ago I wrote about how I wanted to share some information about what I have found to be good childrens' science books (based on reading books to my kids).  Well, here is another one: It's Catching: The Infectious World of Germs and Microbes by Jennifer Gardy and Josh Holinaty.

I first became aware of Jennifer Gardy's talents in making catchy microbe-themed kids material when she released the Youtube video "The A-Z of Epidemiology: germs from Anthrax to Zoonoses. A disturbing bedtime book for kids." which is simply awesome. (Note - great animation by Tom Scott):

 

I watched this video many many many times with my kids - always resulting in painful laughter and entertainment.

I should note that I am collaborating with Jennifer on at least one project (The Kitten Microbiome) and think she is a brilliant scientist and science communicator.  But once I saw her "It's Catching" I realized she really could have a full career as a children's science book and video maker.  It's Catching is both entertaining (like the video) but also educational with information on the history of microbiology and how microbes are studied.  Definitely a good one if you are looking for fun and funny science and/or microbiology themed books for kids.


 

Wednesday, October 22, 2014

Microbe-themed art of the month: Seung-Hwan Oh portraits w/ mold

OK this is pretty cool (from a microbe-art-science point of view): An Artist Who Paints Portraits With Mold | WIRED.  Seung-Hwan Oh "had to set up a micro-fungus farm in his studio" and he puts film in a warm wet environment (note to self - there could be a new human microbiome aspect of this project depending on what warm wet environment is chosen) and sometimes seeds the system with some mold.  And then he lets nature do its work.

See more about his Impermanence works here. (Really - check out the works - they are wild).

At that site the work is described in the following way:
The visual result of the symbiosis between film matter and organic matter is the conceptual origin of this body of work. The process involves the cultivation of emulsion consuming microbes on a visual environment created through portraits and a physical environment composed of developed film immersed in water. As the microbes consume light-sensitive chemical over the course of months or years, the silver halides destabilize, obfuscating the legibility of foreground, background, and scale. This creates an aesthetic of entangled creation and destruction that inevitably is ephemeral, and results in complete disintegration of the film so that it can only be delicately digitized before it is consumed.
Also see his Tumbl page where one can find many other images like this one:


Hat tip to Kate Scow for posting about this on Facebook.

Sunday, October 19, 2014

Kids' Microbiology Book Review: Germ Stories

I was going through some kids' books today and found quite a few that I thought were wonderful and thought - well - I should post about some of them.  So that is what I am going to do.

The first I want to write about is Germ Stories by Arthur Kornberg with Illustrations by Adam Alaniz and Photos by Roberto Kolter.

 

I used to read it to my daughter all the time (she is two years older than my son) and then sometimes, when she was older, she would read it to my son.  A few things I like about this book:
  1. It is not all about pathogens - there are sections on yeast, penicillin, gut microbes and Myxococcus (although it is miswritten as Myxobacterium). 
  2. Everything is done as poetry / songs.  Some are cheesy, but my kids liked them.
  3. Each section on a different microbes has a little poem/song, a drawing, and a picture or two as well as a few mini facts (or I guess, micro facts). 
  4. The material is a bit scary / gross at times but not too over the top.
Anyway - I definitely recommend it if you want a microbiology book that will be good for reading to and reading by kids.

I added this book to a collection I am making via Amazon on "Microbiology Books for Kids".  I will write about some of the other ones at another time.




UPDATE - Wanted other suggestions for good kids' microbiology themed books ...

Wednesday, October 15, 2014

Harvard, hope and hype: the sad reason behind overselling diabetes stem cell work - raising money

Earlier in the week I got all fired up - not in a good way - about a press release and news stories relating to a new paper from Doug Melton on a insulin producing STEM cell study
With a little more discussion I just got more angry


I was angry both about the overselling of the implications of the paper and the fact that the paper was not published in an open manner. This was despite the stated goals of HHMI which funds some of the Melton Lab work.

Monday, October 13, 2014

Talk for UC Davis Pre-Health Meeting (#UCDPHSA): Opening up to Diversity

Sunday I gave a talk at the "12th National UC Davis Pre-Health Student Alliance Pre-Medical and Pre-Health Professions Conference".  I normally try to not give talks on weekends (to spend time with my family) but I made an exception here since this meeting has a strong commitment to issues relating to diversity in health and STEM fields.  This mission statement for the meeting reads:
The UC Davis Pre-Health Student Alliance’s objective is to introduce and support academic, admission, and preparatory opportunities for all students interested in health professions with a focus on those underrepresented in healthcare (with regard to gender, economic, social, educational, linguistic, cultural, racial, and ethnic background). We target universities, community colleges and high schools throughout the United States. The UC Davis Pre-Health Student Alliance aims to impact health education, increase diversity amongst the healthcare workforce, and inspire future leaders of healthcare through hosting the largest national pre-health professions conference.
It was that mission statement that got me to ditch my wife and kids Sunday AM (and also much of Saturday PM for a dinner and to work on my talk).  I went to a dinner Saturday for some of the speakers with the new Dean of the UC Davis School of Medicine Julie Freischlag.  The dinner had about 20 or so people and I met some quite interesting folks there working on various aspects of human and animal health.

And then Sunday AM I got up early, decided to use slides (was not sure) and finished off the slide set I had worked on the night before.  I decided that, in the spirit of the meeting, I would talk about two main things - diversity and access.  And I planned to tell three stories about my work in this area.  I wove in some personal stories since, at the dinner the night before Barbara Ross-Lee (who I sat next to) helped remind me of the importance of making talks personal.  So in the end I talked about myself, diabetes, diversity of microbes, antibiotics, diversity in STEM, and open science.  I came up with a title I was OK with: Opening up to Diversity.

My talk went well, I think.  I am pretty sure it was vbideotaped but not sure where that recording will end up. I did however post my slides to slideshare.  See below:



Opening up to Diversity talk by @phylogenomics at #UCDPHSA from Jonathan Eisen

And I also recorded the talk using Camtasia (basically, it allows recording of the screen, the video camera on my computer, and the audio).  I posted the recording (without the video feed which shows mostly my neck) to Youtube.  See below:




Sunday, October 05, 2014

All Nobel Prizes in 2014 Will be Microbially Themed: The Microbes Guarantee It

So - last year I secretly created a microbiome based spying system that can transmit the thoughts and emails of people who they colonize.  I introduced this community into all the people on the various Nobel Prize committees in order to get information in advance about their plans for the Nobel Prizes. After getting such information, and discovering that the Nobel's this year were NOT focused on microbes, I then created a microbiome-behavioral manipulation system and re-infected the Nobel committees with this community.  This community forces their host to think about microbes all the time.  All microbes.  All the time.  And thus I am nearly 100% certain that all the Nobel's this year will be about microbes in some way.

Given that, here are my predictions for the All-Microbial Nobel Prizes.

Medicine:
The Human Microbiome and Methods for Studying Microbial Communities.  Should go to Norm Pace and some other people.  Possibly Jeff Gordon.  Possibly Jo Handelsman.  Possibly others.  Depends on how much the microbes in the committees emphasize themselves versus all microbes.

Physics:
Vera Rubin for her work on "Dark Matter" since we all know that the key dark matter in the universe is "microbial dark matter".

Chemistry:
Discovery and characterizing of the mechanisms of CRISPRs.  No clue who will get this but it likely could include Jennifer Doudna and Emmanuelle Charpentier and others.

Peace:
Bill and Melinda Gates and their foundation for their work on global health, especially on protecting from infectious diseases.

Literature: Ursula K. Le Guin in particular for her Wrinkle in Time series and its emphasis is on mitochondria.

Economics:
Well, since microcredit has already won an Economics prize, I am not sure how this will play out but certainly it will involve some type of microeconomics.  Definitely NOT macroecnomics. I think the most likely winner here is Esther Duflo because of her work on both microeconomic topics and microcredit.